Overview

This is the analysis of white matter dsi studio connectometry for Loop clousre position error

Methods

Participants

  • Total number of scans = 120 (males and females)

  • Total scans used in analysis= 118

  • Excluded subs 329 and 372 from analyses due to bad behavior data and Subject 347 failed quality control check in DSI

  • Several subjects removed because they did not have rad3 score

Subject numbers for Loop closure task

  • Rad 3
    • All subjects: 38
    • Men: 14
    • Women: 24
    • Stage:
      • Pre: 10
      • Peri: 7
      • Post: 7
  • Average
    • All subjects: 42
    • Men: 17
    • Women: 25
    • Stage:
      • Pre: 11
      • Peri: 7
      • Post: 7

Scan parameters

  • Locations from UCSB and UCI

QSIprep

  • Version used: 0.16.0RC3

  • The following parameters were used

    • dwi_denoise_window 5
    • hmc_model 3dSHORE
    • hmc-transform Rigid
    • shoreline_iters 2
      DSI Studio

  • Version and tags used via singularity container: chen-2022-07-31

  • Parameters

    • T-threshold = 2.5
    • Length = 25
    • Permutation = 4,000
    • pruning 4
    • non normalized QA

Connectronomy analysis methods write up

A diffusion spectrum imaging scheme was used, and a total of 128 diffusion sampling were acquired.The maximum b-value was 4990 s/mm². The in-plane resolution was 1.8 mm. The slice thickness was 1.8 mm. The accuracy of b-table orientation was examined by comparing fiber orientations with those of a population-averaged template (Yeh et al. Neuroimage, 2018). The b-table was flipped by. The diffusion data were reconstructed in the MNI space using q-space diffeomorphic reconstruction (Yeh et al., Neuroimage, 58(1):91-9, 2011) to obtain the spin distribution function (Yeh et al., IEEE TMI, ;29(9):1626-35, 2010). A diffusion sampling length ratio of 1.25 was used. The output resolution in diffeomorphic reconstruction was 1.8 mm isotropic. The tensor metrics were calculated using DWI with b-value lower than 1750 s/mm². The quantitative anisotropy was extracted as the local connectome fingerprint (LCF, Yeh et al. PLoS Comput Biol 12(11): e1005203) and used in the connectometry analysis.

Diffusion MRI connectometry (Yeh et al. NeuroImage 125 (2016): 162-171) was used to derive the correlational tractography that has QA, MD, AD, and RD correlated with Loop Position Error. A nonparametric Spearman partial correlation was used to derive the correlation, and the effect of sex, age_scan_years, and repo_status was removed using a multiple regression model. The total number of subjects varied on analysis (See Analyses and Final sample sizes above). A T-score threshold of 2.5 was assigned and tracked using a deterministic fiber tracking algorithm (Yeh et al. PLoS ONE 8(11): e80713, 2013) to obtain correlational tractography. A seeding region was placed at whole brain (39,49,29) .

The tracks were filtered by topology-informed pruning (Yeh et al. Neurotherapeutics, 16(1), 52-58, 2019) with 4 iteration(s). A length threshold of 25 voxel distance was used to select tracks. To estimate the false discovery rate, a total of 4000 randomized permutations were applied to the group label to obtain the null distribution of the track length.




Behavior

Position error is the straight line distance between the start location and the participants end location. Participants were tested on three different sizes of circles: Radius 1m, 2m, and 3m. For white matter analysis we used the data from radius 3 and an average of performance on all three circle sizes. The average position error on the 1m circle is 0.7237374. The average position error on the 2m circle is 1.6950876. The average position error on the 3m circle is 3.0437896. The average position error across all sizes is 1.771577.

There are no significant differences in performance between men and women on the rad3 loop (t test, p= 0.3776982) or on the avergage of all circles ( p = 0.2106874)





Results

Loop Position Error Rad3

QA

All subjects

Positive Correlations (FDR = 0.077333)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corticospinal_Tract_R 490 55.2333 9.66114 4049
Arcuate_Fasciculus_R 258 52.8135 5.58318 1293
Medial_Lemniscus_R 142 56.1227 6.02296 1599
Corpus_Callosum_Tapetum 82 53.152 6.83284 1949
Dentatorubrothalamic_Tract_R 24 52.5069 4.30703 765
Arcuate_Fasciculus_L 19 53.5862 3.42257 493



Negative Correlations (FDR = 0.001964)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 182 53.8249 8.31103 2920
Cerebellum_L 49 52.8296 4.37448 794



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop position error rad3


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop position error rad3


Glass Brain displaying tracts that had QA positively and negatively correlated with loop position error rad3





Men

Positive Correlations (FDR= 0.074986)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 612 56.9446 10.2611 4709
Corpus_Callosum_Forceps_Minor 367 58.0118 10.7864 5301
Corticospinal_Tract_R 201 58.926 6.683 2067
Cerebellum_R 168 52.7355 8.24409 2815
Inferior_Fronto_Occipital_Fasciculus_R 106 57.7104 6.43346 1876
Arcuate_Fasciculus_L 68 55.3639 6.09813 1617
Vermis 54 53.9354 5.07493 1091
Corpus_Callosum_Tapetum 50 54.9697 6.20826 1664
Superior_Longitudinal_Fasciculus2_R 49 55.6835 5.29033 1224
Medial_Lemniscus_R 49 57.4788 5.34352 1289
Corpus_Callosum_Body 48 55.7614 6.14362 1653
Corticostriatal_Tract_Superior_R 42 55.0071 4.98362 1073
Middle_Cerebellar_Peduncle 30 68.0103 3.33754 595
Corticopontine_Tract_Parietal_R 28 60.1481 4.64214 1018
Corticopontine_Tract_Parietal_L 22 57.0879 4.53962 924
Arcuate_Fasciculus_R 20 53.9119 4.30574 785
Thalamic_Radiation_Posterior_L 20 53.9063 3.65308 565
Corticostriatal_Tract_Posterior_L 19 64.4431 4.32784 948
Cingulum_Frontal_Parietal_L 17 54.4706 1.90957 156
Superior_Longitudinal_Fasciculus3_R 16 56.3938 3.86021 660
Dentatorubrothalamic_Tract_R 12 53.0211 3.0954 399
Thalamic_Radiation_Anterior_R 11 55.113 2.84762 351
Inferior_Longitudinal_Fasciculus_R 10 55.0113 2.93427 372
Parietal_Aslant_Tract_L 10 55.818 2.24525 221



Negative Correlations (FDR = 0.316832)

Not significant




Figures
Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop position error rad3 in men


Glass Brain displaying tracts that had QA positively correlated with loop position error rad3 in men





Women

Positive Correlations (FDR = 0.076923)
.
Cerebellum_L
42
53.7147
4.57498
883



Negative Correlations (FDR = 0.000559)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corticospinal_Tract_R 474 55.9604 9.02897 3583
Medial_Lemniscus_R 198 57.2198 6.17031 1711
Arcuate_Fasciculus_R 137 53.5168 5.07838 1084
Corpus_Callosum_Tapetum 64 55.5103 5.31802 1233
Cingulum_Frontal_Parietal_L 53 54.2412 4.02161 689
Inferior_Longitudinal_Fasciculus_R 47 56.3877 4.46016 881
Corticospinal_Tract_L 37 56.7692 4.82268 1037
Corticostriatal_Tract_Superior_R 24 52.1719 4.33211 769
Dentatorubrothalamic_Tract_R 24 52.8405 4.08343 692
Inferior_Fronto_Occipital_Fasciculus_L 20 52.6101 3.78513 592
Extreme_Capsule_L 14 52.1561 3.02161 374



Figures


Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop position error rad3 in women


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop position error rad3 in women


Glass Brain displaying tracts that had QA positively and negatively correlated with loop position error rad3 in women





pre

Positive Correlations (FDR = 0.035113)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 467 60.7675 10.4772 5239
Corpus_Callosum_Tapetum 369 54.9856 10.7794 5018
Corpus_Callosum_Body 332 59.1764 9.13332 3877
Cerebellum_L 145 55.0137 7.3497 2334
Corpus_Callosum_Forceps_Minor 130 57.4251 6.61573 1974
Fornix_L 63 62.5827 4.14135 843
Fornix_R 42 54.1492 3.35954 480
Arcuate_Fasciculus_L 25 54.8817 2.69041 312
Thalamic_Radiation_Posterior_L 25 54.9735 4.04372 706
Inferior_Longitudinal_Fasciculus_L 19 62.8484 3.86142 736
Inferior_Fronto_Occipital_Fasciculus_L 15 54.2737 2.85726 348
Corticostriatal_Tract_Posterior_L 13 53.6994 3.17069 424
Cingulum_Frontal_Parietal_R 10 61.8106 2.68124 349
Inferior_Longitudinal_Fasciculus_R 10 54.0064 3.01275 385



Negative Correlations (FDR = 0.009547)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Inferior_Fronto_Occipital_Fasciculus_R 334 63.0291 8.13498 3276
Corticospinal_Tract_L 227 56.7152 10.3753 4795
Inferior_Fronto_Occipital_Fasciculus_L 221 55.8831 6.75546 2003
Corticospinal_Tract_R 213 58.3563 8.54936 3350
Cerebellum_L 210 55.8243 7.82411 2684
Middle_Cerebellar_Peduncle 174 55.735 8.04762 2835
Cingulum_Frontal_Parietal_L 172 55.3882 5.88382 1506
Corpus_Callosum_Tapetum 162 59.8389 7.27886 2490
Inferior_Longitudinal_Fasciculus_R 142 57.1087 5.69359 1454
Medial_Lemniscus_L 108 57.3986 6.87698 2132
Corticostriatal_Tract_Superior_L 92 56.2078 7.49821 2482
Arcuate_Fasciculus_L 88 58.4879 6.04751 1680
Cingulum_Parolfactory_R 78 60.8837 4.0928 801
Arcuate_Fasciculus_R 75 62.3341 6.6592 2171
Cingulum_Frontal_Parietal_R 69 56.2722 5.42559 1301
Medial_Lemniscus_R 67 55.8288 5.76046 1455
Dentatorubrothalamic_Tract_L 54 55.127 5.80697 1460
Vermis 52 53.4712 4.60352 890
Corticopontine_Tract_Parietal_L 51 63.3048 4.43966 980
Superior_Longitudinal_Fasciculus2_R 43 58.344 4.97027 1132
Dentatorubrothalamic_Tract_R 41 55.759 5.37456 1265
Cingulum_Frontal_Parahippocampal_L 38 53.5918 4.17878 735
Superior_Longitudinal_Fasciculus2_L 37 54.8211 5.11161 1125
Corpus_Callosum_Body 30 53.0169 4.53403 856
Uncinate_Fasciculus_R 19 56.953 2.89543 375
Cingulum_Frontal_Parahippocampal_R 15 54.9303 2.73622 323
Extreme_Capsule_L 15 58.9499 3.48093 561
Corticopontine_Tract_Parietal_R 13 60.4696 3.29299 515
Corpus_Callosum_Forceps_Major 13 57.3873 2.82224 359
Cingulum_Parolfactory_L 12 54.3225 2.62952 295
Corticostriatal_Tract_Posterior_R 11 54.5534 3.39209 493



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop position error rad3 in pre-menopausal women


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop position error rad3 in pre-menopausal women


Glass Brain displaying tracts that had QA positively and negatively correlated with loop position error rad3 in pre-menopausal women





peri

Positive Correlations (FDR = 0.331167)

No Significant Findings



Negative Correlations (FDR = 0.097716)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 389 65.318 16.4872 13945
Cerebellum_L 282 55.5988 14.5363 9227
Corpus_Callosum_Tapetum 227 63.9398 12.609 7984
Cerebellum_R 216 54.6297 13.8573 8239
Corpus_Callosum_Forceps_Major 215 60.7879 11.9537 6822
Inferior_Fronto_Occipital_Fasciculus_R 200 63.1616 10.8928 5886
Middle_Cerebellar_Peduncle 193 61.3758 12.0195 6964
Arcuate_Fasciculus_R 183 67.7836 10.0947 5425
Superior_Longitudinal_Fasciculus2_R 176 64.0562 10.4205 5463
Corticospinal_Tract_R 144 64.9148 9.72516 4822
Arcuate_Fasciculus_L 136 58.7007 10.6294 5209
Cingulum_Frontal_Parietal_R 118 66.8574 7.7747 3174
Corticostriatal_Tract_Posterior_R 113 65.6592 9.2034 4368
Inferior_Longitudinal_Fasciculus_R 100 60.9458 9.73786 4539
Inferior_Longitudinal_Fasciculus_L 95 62.434 8.71113 3721
Medial_Lemniscus_R 85 63.7718 7.71216 2979
Inferior_Fronto_Occipital_Fasciculus_L 84 63.6238 8.49372 3605
Dentatorubrothalamic_Tract_R 82 59.7679 9.52074 4255
Superior_Longitudinal_Fasciculus2_L 77 60.1905 8.63884 3528
Corticostriatal_Tract_Posterior_L 73 62.1426 8.586 3598
Frontal_Aslant_Tract_L 69 61.3461 8.16996 3216
Corticospinal_Tract_L 65 62.0028 7.61655 2825
Dentatorubrothalamic_Tract_L 64 58.3524 8.51512 3323
Medial_Lemniscus_L 63 58.0775 6.64313 2013
Corticostriatal_Tract_Superior_L 61 56.2701 7.97103 2808
Cingulum_Frontal_Parietal_L 59 60.5532 6.59738 2070
Thalamic_Radiation_Posterior_R 54 60.9672 6.63817 2110
Corticopontine_Tract_Parietal_R 53 61.7509 6.79758 2241
Vermis 53 55.7069 6.6417 1930
Corpus_Callosum_Forceps_Minor 52 56.8889 7.31681 2392
Cingulum_Parahippocampal_Parietal_R 39 56.8344 5.50552 1353
Corticostriatal_Tract_Superior_R 38 61.1728 6.64895 2124
Corticopontine_Tract_Parietal_L 32 66.2582 5.7957 1748
Anterior_Commissure 32 64.3199 5.47813 1516
Superior_Longitudinal_Fasciculus1_R 31 66.141 5.22281 1417
Extreme_Capsule_R 29 62.2185 5.25219 1348
Optic_Radiation_L 27 55.3384 4.67031 948
Cingulum_Parolfactory_R 25 66.9676 4.09735 883
Extreme_Capsule_L 25 58.8064 4.88687 1103
Thalamic_Radiation_Anterior_R 25 63.768 4.98384 1244
Fornix_R 25 67.1349 3.29078 571
Parietal_Aslant_Tract_L 24 57.1033 5.18774 1207
Superior_Longitudinal_Fasciculus3_R 24 61.1716 4.94958 1177
Thalamic_Radiation_Posterior_L 21 57.3387 5.32508 1277
Reticular_Tract_R 20 62.9166 5.0255 1248
Middle_Longitudinal_Fasciculus_R 18 59.0135 4.55819 963
Corticopontine_Tract_Frontal_R 15 60.8106 4.70438 1057
Parietal_Aslant_Tract_R 14 55.2972 3.7508 611
Superior_Longitudinal_Fasciculus3_L 14 58.2923 4.07969 762
Thalamic_Radiation_Superior_R 14 61.4203 4.48189 969
Frontal_Aslant_Tract_R 12 53.3226 3.93357 648
Cingulum_Parolfactory_L 11 59.4667 2.48321 288
Middle_Longitudinal_Fasciculus_L 11 55.8305 3.80245 634
Corticopontine_Tract_Occipital_R 11 66.9093 2.93927 454
Reticular_Tract_L 10 60.4207 3.78266 679



Figures

Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop position error rad3 in peri-menopausal women


Glass Brain displaying tracts that had QA positively and negatively correlated with loop position error rad3 in peri-menopausal women





post

  • No significant results









Peri + Post

Positive Correlations (FDR = 0.058838)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 610 58.0052 11.3173 5835
Corpus_Callosum_Body 567 60.2729 15.4467 11295
Corpus_Callosum_Forceps_Major 216 60.1026 8.37506 3311
Corpus_Callosum_Tapetum 186 53.8132 8.40112 2983
Middle_Cerebellar_Peduncle 168 57.4141 8.9189 3587
Cingulum_Frontal_Parietal_R 120 59.2436 6.42202 1919
Inferior_Fronto_Occipital_Fasciculus_R 73 56.9139 5.40113 1304
Uncinate_Fasciculus_R 60 58.2733 5.3826 1326
Corticospinal_Tract_R 54 63.2633 6.07711 1835
Cingulum_Frontal_Parietal_L 45 56.012 4.16463 763
Cingulum_Parolfactory_R 44 58.9173 4.20446 818
Cingulum_Parolfactory_L 42 53.9153 2.67056 302
Cerebellum_L 28 53.9362 3.75092 596
Medial_Lemniscus_L 21 60.9571 3.81283 696
Cingulum_Frontal_Parahippocampal_R 20 62.7993 3.66912 664
Dentatorubrothalamic_Tract_R 19 59.3764 4.56073 970
Corticostriatal_Tract_Superior_L 17 55.7736 4.52014 895
Frontal_Aslant_Tract_L 14 65.7165 3.05274 481
Corticospinal_Tract_L 13 53.3896 3.61837 549
Superior_Longitudinal_Fasciculus2_R 10 57.0185 2.62254 308
Thalamic_Radiation_Anterior_R 10 57.8096 3.12361 443



Negative Correlations (FDR = 0.103819)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 747 65.6606 13.9656 10058
Cerebellum_R 676 56.1446 15.0471 9984
Corpus_Callosum_Forceps_Major 452 68.9254 11.2899 6900
Corpus_Callosum_Body 430 65.3869 13.335 9132
Corpus_Callosum_Tapetum 284 59.2157 11.2852 5923
Inferior_Fronto_Occipital_Fasciculus_L 259 63.332 8.75312 3811
Corticospinal_Tract_R 241 62.5639 7.8772 3049
Arcuate_Fasciculus_L 148 54.4935 8.06814 2786
Inferior_Longitudinal_Fasciculus_L 102 61.362 6.9487 2327
Cerebellum_L 84 54.9857 6.68685 1931
Medial_Lemniscus_R 83 57.2871 5.75659 1491
Superior_Longitudinal_Fasciculus2_R 76 58.0129 4.85958 1076
Cingulum_Frontal_Parietal_R 71 59.3032 5.50791 1413
Corticostriatal_Tract_Superior_R 49 54.6997 5.53676 1317
Thalamic_Radiation_Posterior_L 47 56.5159 5.20815 1204
Corticostriatal_Tract_Posterior_L 43 59.5929 5.99118 1680
Inferior_Fronto_Occipital_Fasciculus_R 41 55.8663 4.90583 1056
Corticostriatal_Tract_Posterior_R 32 56.9503 4.7519 1010
Thalamic_Radiation_Posterior_R 32 54.262 5.25081 1175
Middle_Longitudinal_Fasciculus_R 26 55.2224 4.88503 1035
Extreme_Capsule_R 25 54.7369 4.10945 726
Corticostriatal_Tract_Superior_L 25 54.1743 4.16755 739
Arcuate_Fasciculus_R 24 57.0949 4.36911 856
Corticostriatal_Tract_Anterior_L 22 55.0136 3.29463 469
Middle_Longitudinal_Fasciculus_L 21 56.1993 3.95952 692
Thalamic_Radiation_Anterior_L 20 60.4115 3.61777 621
Cingulum_Frontal_Parietal_L 19 60.1043 3.72213 654
Corticospinal_Tract_L 16 56.143 3.9299 681
Medial_Lemniscus_L 16 56.2595 3.44039 523
Cingulum_Parolfactory_L 14 58.4268 2.9891 410
Inferior_Longitudinal_Fasciculus_R 13 55.2469 3.79526 625
Corticopontine_Tract_Parietal_R 13 58.9449 3.62694 609
Fornix_L 12 52.4974 3.31829 454
Middle_Cerebellar_Peduncle 11 63.6419 3.29597 543



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop position error rad3 in peri and post-menopausal women


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop position error rad3 in peri and post-menopausal women


Glass Brain displaying tracts that had QA positively and negatively correlated with loop position error rad3 in peri and post-menopausal women





Summary of results

  • QA Tractography using all subjects and controlling for age and sex reveled positive and negative correlations.

  • QA Tractography when looking at men only revealed tracts with positive correlations only. Higher QA scores were associated with higher PE scores. One way to think about this is that poor performers are showing stronger connectivity in regions that are not supporting path integration and this altered recruitment of regions may be associated with worse performance.

  • QA Tractography when looking at women only revealed tracts with negative correlations and positive. Cerebellum was the only tract that was positively correlated with PE score. suggesting that recruitment of PE may be associated with lower path integration performance. NEgative correlations suggest that stronger integrity and connectivity of these regions correlated to lower PE scores and therefore better path integration performance.

  • pre menopausal women displayed both positive and negative tracts suggesting that recruitment of certain regions are differentially associated with performance in path integration

  • Peri menopausal women displayed negative correlations with tracts in the corpus callosum, cerebellum, and several fasciculus tracts.

  • No significant correlations in post menopausal women

  • Peri- post showed positive and negative tracts in several overlapping regions which may be due to low sample size.





MD

All subjects

Positive Correlations (FDR = 1.000000)

No significant results



Negative Correlations (FDR = 0.000616)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 394 56.0872 7.10863 2226
Fornix_L 312 55.1057 7.63814 2525
Thalamic_Radiation_Superior_L 12 52.0137 2.7054 299



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop position error rad3


Glass Brain displaying tracts that had MD negatively correlated with loop position error rad3





Men

Positive Correlations (FDR = 0.058621)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1288 59.2327 9.09596 3849
Fornix_R 192 57.1619 6.21299 1733
Thalamic_Radiation_Superior_L 96 57.3998 5.80086 1517
Corpus_Callosum_Forceps_Major 18 53.905 3.51473 523



Negative Correlations (FDR = 1.000000)

No significant results



Figures

Slice overlay image displaying ROIs with tracts that had MD positively correlated with loop position error rad3 in peri and post-menopausal women


Glass Brain displaying tracts that had MD positively correlated with loop position error rad3 in men





Women

Positive Correlations(FDR = 1.000000)

No Significant Results



Negative Correlations (FDR = 0.000443)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 634 55.6436 8.92995 3485
Fornix_R 253 54.9831 6.34586 1739
Corpus_Callosum_Tapetum 74 58.1445 5.65234 1459
Thalamic_Radiation_Superior_L 64 53.57 5.26208 1165
Corpus_Callosum_Body 49 57.8469 4.22499 811
Optic_Radiation_L 22 56.3585 3.12043 431
Cingulum_Frontal_Parietal_L 13 54.7812 1.5015 97
Corpus_Callosum_Forceps_Major 11 52.5547 2.3962 237



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop position error rad3 in women



Glass Brain displaying tracts that had MD positively and negatively correlated with loop position error rad3 in women





pre

Positive Correlations (FDR = 1.000000)

No Significant Results



Negative Correlations (FDR = 0.044429)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1819 60.5114 11.666 6468
Fornix_R 1031 58.0808 9.61823 4220
Corpus_Callosum_Tapetum 303 61.3149 11.7061 6599
Corpus_Callosum_Forceps_Major 215 62.6589 8.4128 3483
Corpus_Callosum_Body 197 61.8598 11.1996 6094
Cerebellum_R 176 53.9868 7.53284 2406
Thalamic_Radiation_Superior_L 101 53.6068 6.3823 1715
Optic_Radiation_L 56 56.2564 5.17442 1183
Corticostriatal_Tract_Posterior_R 46 55.9619 6.62312 1928
Thalamic_Radiation_Superior_R 27 55.2688 3.93752 673
Cingulum_Frontal_Parietal_L 24 54.2634 3.13177 418
Inferior_Fronto_Occipital_Fasciculus_R 24 57.9236 4.72579 1016
Thalamic_Radiation_Posterior_R 24 55.341 4.86563 1029
Medial_Lemniscus_R 24 53.8532 4.72178 943
Cingulum_Parahippocampal_Parietal_R 22 56.0942 3.5843 566
Cingulum_Frontal_Parietal_R 17 55.533 3.77941 623
Inferior_Fronto_Occipital_Fasciculus_L 15 60.6624 3.42532 559
Middle_Cerebellar_Peduncle 15 54.2922 2.74371 321
Anterior_Commissure 14 65.1589 2.73212 382
Arcuate_Fasciculus_L 13 51.2463 2.84599 326
Middle_Longitudinal_Fasciculus_R 12 70.1754 3.53054 687
Inferior_Longitudinal_Fasciculus_R 11 56.3833 3.54974 558
Arcuate_Fasciculus_R 10 56.0151 3.272 471
Superior_Longitudinal_Fasciculus1_L 10 53.029 2.33459 227
Thalamic_Radiation_Posterior_L 10 76.8091 3.09537 578



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop position error rad3 in pre-menopausal women


Glass Brain displaying tracts that had MD positively and negatively correlated with loop position error rad3 in pre-menopausal women





peri

Positive Correlations(FDR = 1.000000)

No Significant Results



Negative Correlations (FDR = 0.017058)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 137 61.5622 9.16124 4058
Corpus_Callosum_Forceps_Major 117 61.5106 10.1612 4988
Corpus_Callosum_Body 91 63.0188 8.15053 3288
Cerebellum_R 88 54.6434 8.43845 3056
Corticostriatal_Tract_Posterior_R 70 55.4353 7.45229 2418
Fornix_L 70 62.0394 6.31315 1942
Inferior_Longitudinal_Fasciculus_R 61 63.2245 7.60509 2872
Cerebellum_L 51 53.3808 6.54144 1794
Corpus_Callosum_Forceps_Minor 38 59.3224 6.33021 1867
Arcuate_Fasciculus_R 30 58.5445 5.08728 1190
Inferior_Fronto_Occipital_Fasciculus_R 24 58.0717 4.95101 1118
Arcuate_Fasciculus_L 23 56.006 4.44475 869
Inferior_Fronto_Occipital_Fasciculus_L 23 60.4446 5.17427 1271
Inferior_Longitudinal_Fasciculus_L 19 60.4344 4.12335 807
Dentatorubrothalamic_Tract_L 19 55.3776 4.51596 887
Fornix_R 19 59.5998 3.19556 478
Middle_Cerebellar_Peduncle 14 63.7231 3.72648 695
Thalamic_Radiation_Superior_L 13 56.9342 3.70253 613
Corticostriatal_Tract_Posterior_L 12 55.5128 3.57105 556
Dentatorubrothalamic_Tract_R 12 59.83 3.53439 587
Optic_Radiation_L 12 54.9985 3.67064 582
Anterior_Commissure 12 57.3476 3.67409 608
Superior_Longitudinal_Fasciculus2_L 11 58.5526 3.40124 532
Superior_Longitudinal_Fasciculus2_R 11 55.6393 3.60527 568
Cingulum_Frontal_Parietal_L 10 61.2007 3.22524 500
Superior_Longitudinal_Fasciculus1_R 10 57.2059 2.28701 235
Corticospinal_Tract_L 10 53.4043 3.26818 448
Thalamic_Radiation_Posterior_R 10 52.5978 3.59872 535
Reticular_Tract_L 10 62.4156 2.8601 401



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop position error rad3 in peri-menopausal women



Glass Brain displaying tracts that had MD positively and negatively correlated with loop position error rad3 in peri-menopausal women





post

Positive Correlations (FDR = 1.000000)

No Significant Results



Negative Correlations (FDR = 0.064410)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Arcuate_Fasciculus_L 156 61.1147 9.05199 3933
Corpus_Callosum_Forceps_Major 140 60.0388 8.63994 3520
Cerebellum_R 139 54.6339 10.6622 4878
Inferior_Longitudinal_Fasciculus_L 116 62.8715 8.9405 3947
Cerebellum_L 115 54.0622 9.27667 3654
Fornix_L 89 54.4819 6.04764 1565
Corpus_Callosum_Tapetum 81 59.2701 8.44513 3320
Inferior_Longitudinal_Fasciculus_R 77 58.9461 8.47213 3323
Superior_Longitudinal_Fasciculus2_L 68 58.1598 7.05413 2273
Corpus_Callosum_Body 63 57.3084 8.31507 3112
Inferior_Fronto_Occipital_Fasciculus_R 45 56.3659 6.85454 2080
Corpus_Callosum_Forceps_Minor 44 60.1086 6.44011 1958
Corticostriatal_Tract_Posterior_L 39 63.8606 5.85262 1718
Corticostriatal_Tract_Posterior_R 33 56.7263 5.57555 1385
Thalamic_Radiation_Superior_L 30 59.4745 4.03364 760
Thalamic_Radiation_Posterior_L 25 55.5278 5.47441 1307
Middle_Cerebellar_Peduncle 24 60.1675 5.10806 1233
Superior_Longitudinal_Fasciculus2_R 23 57.9138 5.01726 1145
Frontal_Aslant_Tract_L 21 63.5285 4.41825 974
Fornix_R 19 56.2117 3.07702 418
Inferior_Fronto_Occipital_Fasciculus_L 15 58.4104 4.4782 920
Parietal_Aslant_Tract_L 14 59.4525 2.82255 372
Dentatorubrothalamic_Tract_L 14 56.1464 3.82153 644
Medial_Lemniscus_R 14 61.4312 4.23907 867
Arcuate_Fasciculus_R 13 54.7848 3.80818 624
Corticostriatal_Tract_Anterior_L 13 55.86 3.83726 646
Corticostriatal_Tract_Anterior_R 13 54.008 4.20771 751
Corticostriatal_Tract_Superior_L 11 56.0279 3.5128 543



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop position error rad3 in post-menopausal women


Glass Brain displaying tracts that had MD positively and negatively correlated with loop position error rad3 in post-menopausal women





Peri + Post

Positive Correlations (FDR = 1.000000)

No Significant Results



Negative Correlations (FDR = 0.161324)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 400 58.6692 8.11042 3031
Corpus_Callosum_Tapetum 383 59.2374 10.4802 5110
Cerebellum_R 97 53.4518 6.60958 1834
Corpus_Callosum_Forceps_Major 54 60.3021 5.40771 1385
Corpus_Callosum_Body 50 57.8098 5.57465 1411
Thalamic_Radiation_Superior_L 48 57.2993 4.26601 819
Fornix_R 25 51.9201 3.55033 514
Inferior_Fronto_Occipital_Fasciculus_L 15 56.6684 3.31466 489
Cerebellum_L 14 50.7299 3.14464 394
Cingulum_Frontal_Parietal_L 13 56.4625 2.41671 259
Inferior_Longitudinal_Fasciculus_R 13 58.1644 3.03936 422
Middle_Cerebellar_Peduncle 13 54.3025 2.23478 213



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop position error rad3 in peri and post-menopausal women


Glass Brain displaying tracts that had MD positively and negatively correlated with loop position error rad3 in peri and post-menopausal women





Summary of results

  • MD Tractography of all subjects, regressing age and sex, revealed tracts negatively correlated with PE score in the fornix and thalamic radiation. This suggests that subjects with lower PE score displayed increased diffusivity in these regions. Perhaps we see this because they scored so low due to having lower connectivity in these regions.

  • MD Tractography of men only, regressing age , revealed tracts positively correlated with PE score. lower MD in fornix, and thalamic radiation was associated with lower PE score and therefore better performance.

  • MD Tractography of women only, regressing age , revealed tracts negatively correlated with PE score. lower MD in fornix, and thalamic radiation was associated with higher PE score.

  • MD Tractography of pre, peri, post adn combined peri post menopausal women only, regressing age , revealed tracts negatively correlated with PE score. lower MD in fornix, and thalamic radiation was associated with higher PE score.







RD

All subjects

Positive Correlations (FDR = 0.625000)

No significant correlations



Negative Correlations (FDR = 0.000639)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 429 55.5107 6.94688 2104
Fornix_L 293 55.8203 7.44036 2427



Figures

Slice overlay image displaying ROIs with tracts that had RD negatively correlated with loop position error rad3


Glass Brain displaying tracts that had RD negatively correlated with loop position error rad3





Men

Positive Correlations (FDR = 0.057317)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1339 59.5003 9.2147 3968
Fornix_R 186 56.0247 6.09011 1632
Thalamic_Radiation_Superior_L 97 56.4795 5.6199 1401
Corpus_Callosum_Forceps_Major 25 55.5253 3.91379 668



Negative Correlations Not significant (1.000000)

No significant results



Figures

Slice overlay image displaying ROIs with tracts that had RD positively correlated with loop position error rad3 in men


Glass Brain displaying tracts that had RD positively correlated with loop position error rad3 in men





Women

Positive Correlations (FDR = 1.000000)

No significant results



Negative Correlations (FDR = 0.002117)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1042 56.0036 10.0301 4425
Fornix_R 577 55.6089 7.64404 2552
Corpus_Callosum_Body 121 56.4221 6.90199 2111
Corpus_Callosum_Tapetum 96 57.9274 5.95614 1614
Thalamic_Radiation_Superior_L 90 55.0884 5.56723 1341
Cingulum_Frontal_Parietal_L 14 56.2972 2.15322 205
Corpus_Callosum_Forceps_Major 12 51.5018 2.60267 274



Figures

Slice overlay image displaying ROIs with tracts that had RD negatively correlated with loop position error rad3

Glass Brain displaying tracts that had RD positively correlated with loop position error rad3





pre

Positive Correlations (FDR = 1.000000)

No significant correlations



Negative Correlations (FDR = 0.033719)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1177 60.2053 10.319 5035
Fornix_R 455 57.4181 7.46495 2513
Corpus_Callosum_Forceps_Major 101 59.9111 6.57472 2034
Corpus_Callosum_Tapetum 87 60.103 6.74723 2149
Corpus_Callosum_Body 73 60.9683 6.62236 2100
Cerebellum_R 59 53.4923 4.9273 1020
Thalamic_Radiation_Superior_L 37 54.2194 4.37478 815
Cingulum_Frontal_Parietal_L 12 53.5183 1.41366 84



Figures

Slice overlay image displaying ROIs with tracts that had RD negatively correlated with loop position error rad3 in peri menopausal women


Glass Brain displaying tracts that had RD negatively correlated with loop position error rad3





peri

Positive Correlations (FDR = 1.000000)

No significant results



Negative Correlations (FDR = 0.016568)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 118 59.7426 9.48688 4223
Corpus_Callosum_Forceps_Major 110 60.3932 9.31986 4120
Corpus_Callosum_Tapetum 93 60.8031 8.26103 3259
Cerebellum_R 80 53.9785 8.11526 2792
Fornix_L 70 62.0735 6.20158 1875
Corpus_Callosum_Forceps_Minor 63 57.4473 7.31003 2411
Cerebellum_L 54 53.4506 7.06095 2093
Inferior_Longitudinal_Fasciculus_R 23 60.1915 5.02983 1196
Corticostriatal_Tract_Posterior_R 22 53.2808 4.93707 1020
Thalamic_Radiation_Posterior_R 20 54.3022 4.69473 940
Arcuate_Fasciculus_R 19 55.0666 4.24676 780
Fornix_R 17 56.4813 3.0989 426
Cingulum_Frontal_Parietal_L 14 56.8687 3.53139 557
Middle_Cerebellar_Peduncle 14 59.8633 3.77214 669
Dentatorubrothalamic_Tract_L 13 57.3816 3.68205 611
Cingulum_Parolfactory_R 11 66.5657 2.11562 234
Dentatorubrothalamic_Tract_R 11 53.0841 3.89034 631
Reticular_Tract_R 11 56.5545 3.02704 407
Reticular_Tract_L 10 62.7878 3.05751 461



Figures

Slice overlay image displaying ROIs with tracts that had RD negatively correlated with loop position error rad3 in peri menopausal women


Glass Brain displaying tracts that had RD negatively correlated with loop position error rad3 in peri menopausal women





post

Positive Correlations (FDR = 1.000000)

No significant results



Negative Correlations (FDR = .065219))
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 429 55.5107 6.94688 2104
Fornix_L 293 55.8203 7.44036 2427



Figures

Slice overlay image displaying ROIs with tracts that had RD negatively correlated with loop position error rad3 in post menopausal women


Glass Brain displaying tracts that had RD negatively correlated with loop position error rad3 in post menopausal women





Peri + Post

Positive Correlations (FDR = 1.000000)

Not significant



Negative Correlations (FDR = 0.157199)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 379 57.8998 7.89017 2831
Corpus_Callosum_Tapetum 263 60.9206 8.76398 3675
Cingulum_Frontal_Parietal_R 69 57.5121 5.50927 1371
Cerebellum_R 69 53.4002 5.32892 1191
Thalamic_Radiation_Superior_L 50 56.4934 4.54116 915
Corpus_Callosum_Forceps_Major 48 60.0107 5.79171 1581
Corpus_Callosum_Forceps_Minor 47 54.8602 5.28396 1203
Fornix_R 37 52.9241 4.29562 767
Corpus_Callosum_Body 35 55.149 5.00266 1084
Corticospinal_Tract_L 31 53.2934 3.87962 630
Frontal_Aslant_Tract_L 28 56.2125 2.99493 396
Corticospinal_Tract_R 27 64.5277 3.77181 721
Inferior_Longitudinal_Fasciculus_L 24 52.254 3.83631 604
Cingulum_Frontal_Parietal_L 22 54.3651 4.02285 691
Cingulum_Parolfactory_R 20 57.3119 3.39887 520
Dentatorubrothalamic_Tract_R 19 60.5413 3.71717 657
Middle_Cerebellar_Peduncle 12 54.0049 2.13313 193



Figures

Slice overlay image displaying ROIs with tracts that had RD positively correlated with loop position error rad3 in peri and post menopausal women


Slice overlay image displaying ROIs with tracts that had RD negatively correlated with loop position error rad3 in peri and post menopausal women


Glass Brain displaying tracts that had RD positively and negatively correlated with loop position error rad3 in peripost menopausal women





Summary of results

  • RD tractography of all subs showed negative correlations. Suggesting that higher RD is associated with decreased PE score. Better performers have increased RD in fornix, perhaps they are not using these regions to complete the task. part of the reson they may have done so poorly is because they attempted to rely on fornix and there’s less connectivity there.

-AD tractography of men only showed positive and negative scores. only one region was negative and the rest of the ROIs were positive. Positive correlations suggest that lower AD is associated with lower PE score. It may be that poor performers are recruiting these regions that are showing increased wide spread diffusivity or lower connectivity.

-AD tractography of wmen only showed negative correlations. Negative correlations suggest that lower AD is associated with higher PE scores and worse performance. It amy be that women who have better path integration show strong recruitment of these areas.

Tracts with RD displayed negative correlations with PE. In men, this was opposite with men displaying positive correlations. Women, and those in the peri and post stages displayed negative correlations. Those in the pre and peri+post group displayed positive and negative correlations.







Overall Summary

Loop task is more dependent on egocentric regions which may be why we see that better performers are those that have better QA in regions not in parietal lobe.

Men’s performance suggest that those with lower PE scores are relying on stronger connectivity in fornix regions and less in cerebellum and corpus callosum.

While women may be relying on regions such as corpus callosum, cingulum, fasciculus over fornix to perform better.

Loop Position Error Average

QA

All subjects

Positive Correlations (FDR = 0.000547)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 1098 55.1403 11.7843 6014
Cingulum_Frontal_Parahippocampal_R 13 53.2308 2.4697 255
Cingulum_Frontal_Parahippocampal_L 10 58.6 2.04248 192
Cingulum_Frontal_Parietal_L 10 51 1.86954 140



Negative Correlations (FDR = 0.015697)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corticospinal_Tract_R 310 54.9742 8.89086 3413
Corpus_Callosum_Forceps_Major 212 55.6321 7.53083 2478
Arcuate_Fasciculus_L 120 54.6667 6.6872 1920
Cerebellum_R 109 52.8073 7.58319 2385
Medial_Lemniscus_R 98 56.0612 6.43806 1825
Cerebellum_L 64 52.125 4.98417 1017
Arcuate_Fasciculus_R 55 52.4727 3.82831 604
Corpus_Callosum_Tapetum 48 53.4167 4.93804 1023
Dentatorubrothalamic_Tract_R 17 53.6471 3.68451 572
Corticostriatal_Tract_Superior_R 13 53.2308 3.12012 407
Cingulum_Frontal_Parietal_L 12 51.6667 2.75055 307
Vermis 11 53.0909 2.52097 265
Anterior_Commissure 10 56.2 1.92756 164



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop position error average


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop position error average


Glass Brain displaying tracts that had QA positively and negatively correlated with loop position error average







Men

Positive Correlations (FDR = 0.154305)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 467 56.6595 11.2379 5620
Cerebellum_L 217 55.3456 8.79452 3362
Corticospinal_Tract_R 42 56.4286 4.68075 971
Cerebellum_R 27 53.037 4.22338 743
Inferior_Fronto_Occipital_Fasciculus_R 24 57.75 3.59748 587
Cingulum_Frontal_Parietal_L 20 58.3 2.36451 256
Cingulum_Frontal_Parietal_R 16 57.125 2.22443 222
Arcuate_Fasciculus_R 15 51.2 3.66791 541
Vermis 12 52.1667 3.3725 466
Superior_Longitudinal_Fasciculus2_R 10 51.6 3.10612 391



Negative Correlations (FDR = 0.036522)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 537 54.5251 11.8328 5996
Corpus_Callosum_Forceps_Major 149 57.8792 6.88362 2154
Cerebellum_R 59 53.5593 5.28064 1173
Vermis 23 53.8261 3.07986 401
Corpus_Callosum_Tapetum 20 55.1 3.40928 503



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop position error average


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop position error average


Glass Brain displaying tracts that had QA positively and negatively correlated with loop position error average







Women

Positive Correlations (FDR = 0.008475)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 66 53.4545 6.03682 1530
Cerebellum_L 23 54.5217 2.88738 357



Negative Correlations (FDR = 0.000699)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corticospinal_Tract_R 407 55.6085 8.74234 3338
Medial_Lemniscus_R 205 57.0938 6.28803 1773
Arcuate_Fasciculus_R 91 53.1318 4.89283 999
Corticostriatal_Tract_Superior_R 47 53.6668 4.94335 1030
Cingulum_Frontal_Parietal_L 34 52.3095 3.15905 410
Dentatorubrothalamic_Tract_R 32 52.136 4.28828 753
Corpus_Callosum_Tapetum 31 52.8476 4.70544 919
Corpus_Callosum_Body 12 52.1791 3.33937 457



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop position error average


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop position error average


Glass Brain displaying tracts that had QA positively and negatively correlated with loop position error average





pre

Positive Correlations (FDR = 0.041934)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 604 62.1358 11.1214 6036
Corpus_Callosum_Tapetum 406 54.5665 10.9216 5112
Corpus_Callosum_Body 273 59.1429 8.58936 3427
Corpus_Callosum_Forceps_Minor 263 58.9125 8.14289 3068
Cerebellum_L 224 56.25 8.01352 2837
Fornix_L 62 56.7742 4.35577 846
Arcuate_Fasciculus_L 36 54.3333 3.17805 431
Fornix_R 34 53 3.184 422
Inferior_Longitudinal_Fasciculus_L 23 56.6087 4.67329 971
Corticostriatal_Tract_Posterior_L 17 55.0588 3.27214 463
Inferior_Longitudinal_Fasciculus_R 15 51.8667 3.09416 390
Thalamic_Radiation_Posterior_L 11 52.5454 2.54357 267



Negative Correlations (FDR = 0.007904)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Inferior_Fronto_Occipital_Fasciculus_R 373 67.0724 8.01372 3383
Cerebellum_L 206 54.9515 7.54976 2460
Inferior_Fronto_Occipital_Fasciculus_L 140 57.7571 6.01643 1642
Corpus_Callosum_Tapetum 131 60.855 6.16234 1815
Cingulum_Frontal_Parietal_L 116 54.7931 5.31568 1216
Corticospinal_Tract_R 106 59.0943 6.7089 2089
Corticospinal_Tract_L 88 55.5909 7.11458 2210
Middle_Cerebellar_Peduncle 84 55.8333 6.77364 2012
Inferior_Longitudinal_Fasciculus_R 79 56.6582 5.5567 1374
Arcuate_Fasciculus_R 78 60.3333 5.84159 1617
Vermis 60 53.5333 5.27967 1172
Cingulum_Parolfactory_R 57 63.193 3.55147 626
Corticostriatal_Tract_Superior_L 51 55.5294 5.60063 1368
Cingulum_Frontal_Parietal_R 45 57.1111 5.15289 1191
Medial_Lemniscus_R 33 54.1212 4.94639 1040
Medial_Lemniscus_L 31 54.8387 4.74811 971
Superior_Longitudinal_Fasciculus2_R 30 54.1333 4.48704 856
Dentatorubrothalamic_Tract_R 25 57.6 3.95324 707
Arcuate_Fasciculus_L 24 56.8333 3.44906 531
Cingulum_Frontal_Parahippocampal_R 18 54 2.81467 336
Dentatorubrothalamic_Tract_L 17 56.8235 3.7512 628
Corpus_Callosum_Body 16 60.75 3.62506 627
Cingulum_Frontal_Parahippocampal_L 12 52.5 3.27776 443



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop position error average


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop position error average


Glass Brain displaying tracts that had QA positively and negatively correlated with loop position error average







peri

Positive Correlations (FDR = 0.649718)



Negative Correlations (FDR = 0.020944)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 277 65.1625 14.8355 11264
Cerebellum_L 239 55.7657 14.1327 8748
Corpus_Callosum_Tapetum 217 63.9724 12.4605 7801
Inferior_Fronto_Occipital_Fasciculus_R 206 62.9417 10.8709 5842
Superior_Longitudinal_Fasciculus2_R 186 63.7312 10.4289 5444
Middle_Cerebellar_Peduncle 181 62.0442 11.717 6690
Arcuate_Fasciculus_R 175 68.5486 10.003 5387
Corpus_Callosum_Forceps_Major 161 60.4224 10.793 5528
Corticospinal_Tract_R 154 66.6883 9.81822 5049
Cingulum_Frontal_Parietal_R 144 66.7083 7.96518 3324
Cerebellum_R 140 54.4143 12.3988 6570
Arcuate_Fasciculus_L 137 57.9562 10.3838 4908
Corticostriatal_Tract_Posterior_R 123 66.0813 9.31776 4506
Inferior_Longitudinal_Fasciculus_L 99 61.2525 8.58786 3548
Medial_Lemniscus_R 95 64.6737 7.81218 3100
Inferior_Longitudinal_Fasciculus_R 93 60.7097 9.51298 4315
Dentatorubrothalamic_Tract_R 93 60.5591 9.99442 4751
Superior_Longitudinal_Fasciculus2_L 81 59.8519 8.70122 3559
Inferior_Fronto_Occipital_Fasciculus_L 78 64.1538 8.11732 3320
Frontal_Aslant_Tract_L 71 60.6479 8.0699 3102
Corticostriatal_Tract_Posterior_L 70 61.9714 8.51742 3531
Dentatorubrothalamic_Tract_L 58 58.8966 7.98856 2952
Corticopontine_Tract_Parietal_R 57 62.1754 6.99738 2391
Medial_Lemniscus_L 56 58.2143 6.27795 1802
Corticostriatal_Tract_Superior_L 55 56.5818 7.56615 2544
Cingulum_Frontal_Parietal_L 54 60.7778 6.27736 1881
Corticospinal_Tract_L 54 60.7778 7.23835 2501
Vermis 52 55.9231 6.76484 2010
Thalamic_Radiation_Posterior_R 51 61.098 6.54088 2053
Corticostriatal_Tract_Superior_R 40 62.85 6.73788 2241
Cingulum_Parahippocampal_Parietal_R 39 57.0256 5.48001 1345
Superior_Longitudinal_Fasciculus1_R 38 67.5263 5.49604 1602
Thalamic_Radiation_Anterior_R 37 65.3513 5.64745 1637
Anterior_Commissure 35 65.3714 5.31978 1453
Corpus_Callosum_Forceps_Minor 32 58.1875 6.11342 1708
Corticopontine_Tract_Parietal_L 31 68.3226 5.46051 1600
Superior_Longitudinal_Fasciculus3_R 29 60.4828 5.09266 1232
Cingulum_Parolfactory_R 28 67.0714 4.38738 1014
Extreme_Capsule_R 28 64.4286 4.99396 1262
Parietal_Aslant_Tract_L 23 58.4348 4.81719 1065
Superior_Longitudinal_Fasciculus3_L 22 58.3636 4.82691 1068
Reticular_Tract_R 22 62.1818 5.17124 1306
Extreme_Capsule_L 21 60.381 4.72333 1058
Thalamic_Radiation_Posterior_L 20 57.1 5.17498 1201
Thalamic_Radiation_Superior_R 19 64 4.77691 1147
Optic_Radiation_L 19 56.1053 4.20457 779
Middle_Longitudinal_Fasciculus_R 18 58.6667 4.52632 944
Corticopontine_Tract_Frontal_R 18 59.7778 4.76948 1068
Corticopontine_Tract_Occipital_R 15 65.4667 3.24672 542
Frontal_Aslant_Tract_R 14 54 3.98351 673
Parietal_Aslant_Tract_R 13 54.9231 3.74193 604
Reticular_Tract_L 12 62.6667 4.11395 833
Middle_Longitudinal_Fasciculus_L 11 55.8182 3.80287 634



Figures

Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop position error average


Glass Brain displaying tracts that had QA positively and negatively correlated with loop position error average







post

Positive Correlations (FDR = 1.000000)



Negative Correlations (FDR = 0.140042)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 2857 69.9748 27.5066 41582
Corpus_Callosum_Forceps_Minor 1116 69.2957 17.8912 17421
Corpus_Callosum_Forceps_Major 1070 77.8392 16.3591 16361
Arcuate_Fasciculus_L 776 72.0335 14.9212 12596
Corpus_Callosum_Tapetum 715 66.442 16.3525 13954
Cerebellum_R 675 57.5319 18.5378 15528
Corticospinal_Tract_R 380 64.8895 11.804 7101
Inferior_Longitudinal_Fasciculus_L 284 68.5775 12.0062 7764
Cerebellum_L 269 56.0149 14.0042 8628
Inferior_Fronto_Occipital_Fasciculus_L 268 71.6642 11.4375 7363
Cingulum_Frontal_Parietal_L 260 69.3154 9.80428 5233
Inferior_Fronto_Occipital_Fasciculus_R 254 70.9213 11.3874 7223
Superior_Longitudinal_Fasciculus2_L 251 62.9163 12.3182 7498
Dentatorubrothalamic_Tract_R 231 61.6537 12.4445 7499
Medial_Lemniscus_R 229 63.9039 10.3351 5361
Corticostriatal_Tract_Posterior_L 215 67.9907 10.7299 6148
Middle_Cerebellar_Peduncle 210 60.5429 12.4775 7403
Corticospinal_Tract_L 183 62.0874 11.1432 6055
Dentatorubrothalamic_Tract_L 180 59.8111 12.1003 6878
Cingulum_Frontal_Parietal_R 171 65.3801 9.2578 4401
Corticostriatal_Tract_Posterior_R 171 59.4152 10.6974 5340
Inferior_Longitudinal_Fasciculus_R 160 60.725 11.5306 6341
Corticostriatal_Tract_Superior_L 143 58.6434 10.7292 5302
Frontal_Aslant_Tract_L 141 63.7163 10.4492 5464
Corticostriatal_Tract_Superior_R 140 58.1429 10.0671 4628
Extreme_Capsule_L 134 66.9254 8.85766 4124
Medial_Lemniscus_L 131 62.8397 9.21393 4190
Superior_Longitudinal_Fasciculus2_R 130 59.3385 11.0203 5660
Arcuate_Fasciculus_R 116 60.3621 9.136 3957
Parietal_Aslant_Tract_L 113 60.3894 7.34818 2561
Thalamic_Radiation_Posterior_L 103 60.7379 8.39007 3358
Middle_Longitudinal_Fasciculus_R 90 65.2222 7.20606 2660
Middle_Longitudinal_Fasciculus_L 86 63.6977 7.44909 2776
Thalamic_Radiation_Anterior_R 85 64.4 8.28399 3471
Frontal_Aslant_Tract_R 73 60.9863 8.06303 3114
Corticopontine_Tract_Parietal_R 70 67.0286 6.3832 2145
Thalamic_Radiation_Anterior_L 69 60.5507 7.40115 2605
Thalamic_Radiation_Posterior_R 69 61.4203 7.17443 2483
Extreme_Capsule_R 68 63.1765 6.59329 2157
Superior_Longitudinal_Fasciculus1_L 67 62.3582 6.16427 1861
Superior_Longitudinal_Fasciculus3_L 66 65.2727 7.11198 2593
Corticopontine_Tract_Parietal_L 66 65.0909 7.08335 2565
Fornix_L 65 58.4923 7.35477 2485
Thalamic_Radiation_Superior_L 55 63.4545 7.74438 2989
Superior_Longitudinal_Fasciculus1_R 52 58.1538 6.08288 1690
Thalamic_Radiation_Superior_R 52 62.6154 7.0669 2456
Parietal_Aslant_Tract_R 47 56.5957 6.07044 1638
Superior_Longitudinal_Fasciculus3_R 46 58.1739 6.58133 1979
Reticular_Tract_R 46 62.6087 6.90278 2343
Reticular_Tract_L 41 59.561 5.79512 1571
Anterior_Commissure 41 57.8049 6.25629 1777
Uncinate_Fasciculus_R 40 67.65 4.98623 1321
Corticostriatal_Tract_Anterior_R 39 54.5641 6.52579 1825
Cingulum_Parolfactory_R 38 66.3684 4.72147 1162
Cingulum_Frontal_Parahippocampal_L 36 69.6667 5.41433 1604
Cingulum_Parahippocampal_Parietal_R 36 61.9444 4.9207 1178
Corticostriatal_Tract_Anterior_L 32 56.0625 6.09924 1638
Cingulum_Parahippocampal_Parietal_L 30 57.3333 4.85639 1062
Cingulum_Parolfactory_L 28 58.5 5.16983 1228
Fornix_R 25 60 3.81819 687
Superior_Cerebellar_Peduncle 25 58.32 4.44499 905
Cingulum_Frontal_Parahippocampal_R 18 60.2222 3.55869 599
Corticopontine_Tract_Occipital_R 14 66 3.65109 691
Inferior_Cerebellar_Peduncle_L 14 55.2857 3.31442 477
Corticopontine_Tract_Occipital_L 12 60 3.53239 588
Corticopontine_Tract_Frontal_L 10 57 3.60251 581
Optic_Radiation_L 10 52.6 3.61542 540



Figures

Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop position error average


Glass Brain displaying tracts that had QA positively and negatively correlated with loop position error average







Peri and Post

Positive Correlations (FDR = 0.000776)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 467 57.2719 10.2578 4733
Corpus_Callosum_Body 93 55.9785 7.06742 2196
Inferior_Fronto_Occipital_Fasciculus_R 42 54.3333 4.68338 936
Uncinate_Fasciculus_R 32 56.0625 4.34691 832
Cerebellum_L 25 52.88 3.9071 634
Cingulum_Parolfactory_R 19 56.5263 1.83199 149
Middle_Cerebellar_Peduncle 14 56.1429 3.16248 441
Cingulum_Parolfactory_L 13 53.3846 1.82077 139



Negative Correlations (FDR = 0.000529)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 381 61.3071 12.04 6980
Corpus_Callosum_Tapetum 210 57.9905 8.46808 3266
Corpus_Callosum_Forceps_Major 202 63.6832 7.77174 3021
Corticospinal_Tract_R 118 59.1695 6.78916 2142
Arcuate_Fasciculus_L 90 57.0444 6.1126 1674
Superior_Longitudinal_Fasciculus2_R 52 56.9615 4.12978 763
Medial_Lemniscus_R 49 57.4694 5.09784 1173
Corticostriatal_Tract_Superior_R 33 53.8788 4.11629 717
Thalamic_Radiation_Posterior_L 29 54.8966 3.96549 678
Cingulum_Frontal_Parietal_R 19 53.7895 2.92321 361
Cingulum_Parolfactory_L 17 56.3529 2.40501 256
Corticostriatal_Tract_Superior_L 12 52 2.69669 297
Corpus_Callosum_Forceps_Minor 12 53.5 3.04266 389
Cerebellum_R 12 53 2.51359 263



Figures


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop position error average


Glass Brain displaying tracts that had QA positively and negatively correlated with loop position error average





Summary







MD

All subjects

Positive Correlations (FDR = 0.997701)



Negative Correlations (FDR = 0.019688 )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 1047 56.4546 7.41367 2437
Fornix_L 842 56.1924 8.61828 3278
Corpus_Callosum_Tapetum 86 55.8372 5.38775 1273
Corpus_Callosum_Body 85 54.7765 6.19298 1650
Cingulum_Frontal_Parietal_L 67 56 4.0008 704
Thalamic_Radiation_Superior_L 50 54.16 5.07368 1095



Figures

Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop position error average


Glass Brain displaying tracts that had QA positively and negatively correlated with loop position error average







Men

Positive Correlations (FDR = 0.022854 )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 6541 59.2815 12.8683 7710
Fornix_R 1480 55.8662 10.3552 4705
Thalamic_Radiation_Superior_L 1113 57.0548 10.1966 4659
Corpus_Callosum_Forceps_Major 551 58.8167 8.29303 3177
Cingulum_Frontal_Parietal_L 195 59.7436 5.65022 1498
Thalamic_Radiation_Posterior_L 112 55.875 5.90076 1528
Cerebellum_L 111 52.3604 5.54405 1264
Thalamic_Radiation_Superior_R 102 54.1765 4.9723 1052
Corpus_Callosum_Tapetum 58 54.069 5.34676 1214
Thalamic_Radiation_Anterior_L 48 52.0833 3.70658 562
Cingulum_Frontal_Parahippocampal_L 39 64.9231 4.21056 904
Arcuate_Fasciculus_L 14 56.1429 2.78904 343
Medial_Lemniscus_L 13 52 2.97308 361
Optic_Radiation_L 12 53.1667 3.13348 410



Negative Correlations (FDR = 0.247381)

No significant tracts



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop position error average


Glass Brain displaying tracts that had QA positively and negatively correlated with loop position error average







Women

Positive Correlations (FDR = 0.125000)

no significant tracts



Negative Correlations (FDR = 0.000576 )

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 2100 57.8505 11.3818 5886
Fornix_R 864 57.2083 8.42334 3188
Corpus_Callosum_Tapetum 410 58.8585 10.5876 5182
Corpus_Callosum_Body 297 59.6094 9.22712 3986
Thalamic_Radiation_Superior_L 251 57.3227 7.42792 2484
Cingulum_Frontal_Parietal_L 80 59.45 4.22125 832
Optic_Radiation_L 39 56.4103 3.42592 520
Corpus_Callosum_Forceps_Major 35 57.5429 3.9017 688
Thalamic_Radiation_Superior_R 24 54.4167 3.75931 604
Inferior_Fronto_Occipital_Fasciculus_L 19 55.5789 3.20718 449
Cerebellum_R 19 53.0526 3.32983 462
Thalamic_Radiation_Posterior_L 17 62.3529 2.98038 435
Uncinate_Fasciculus_R 13 54 2.9296 364
Thalamic_Radiation_Anterior_L 12 57.3333 2.3797 255



Figures

Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop position error average


Glass Brain displaying tracts that had QA positively and negatively correlated with loop position error average





pre

Positive Correlations (FDR = 1.0000)

no significant tracts



Negative Correlations (FDR = 0.033976)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 750 59.8453 8.68579 3546
Fornix_R 238 56.8824 5.65565 1429
Cerebellum_R 103 55.2621 5.48126 1304
Corpus_Callosum_Forceps_Major 26 56.6923 3.79422 641
Thalamic_Radiation_Superior_L 21 53.2381 3.05405 390
Corpus_Callosum_Tapetum 21 57.0476 3.65942 600
Optic_Radiation_L 12 55.5 2.60147 295
Corpus_Callosum_Body 12 56.6667 2.8043 350
Cingulum_Frontal_Parietal_L 11 51.8182 1.3844 78



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop position error average


Glass Brain displaying tracts that had MD positively and negatively correlated with loop position error average







peri

Positive Correlations (FDR = 1.0000)

no significant tracts



Negative Correlations (FDR = 0.016885)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 133 61.7895 9.04126 3967
Corpus_Callosum_Forceps_Major 125 62.208 9.96534 4852
Cerebellum_R 90 54.6889 8.49819 3102
Corpus_Callosum_Body 87 63.8391 8.22628 3393
Fornix_L 78 61.641 6.27289 1905
Corticostriatal_Tract_Posterior_R 72 55.3611 7.3969 2379
Inferior_Longitudinal_Fasciculus_R 60 63.4 7.4867 2791
Cerebellum_L 48 53.5 6.33254 1685
Corpus_Callosum_Forceps_Minor 43 59.8605 6.54183 2012
Arcuate_Fasciculus_R 32 58.375 5.05598 1172
Inferior_Fronto_Occipital_Fasciculus_L 31 59.9355 5.19006 1268
Dentatorubrothalamic_Tract_L 24 55.0833 4.77885 988
Arcuate_Fasciculus_L 23 55.4783 4.47611 873
Inferior_Fronto_Occipital_Fasciculus_R 23 58.2609 4.94075 1117
Fornix_R 23 60.8696 3.68165 648
Thalamic_Radiation_Superior_L 19 57.5789 3.83761 666
Middle_Cerebellar_Peduncle 19 62.4211 3.91911 753
Inferior_Longitudinal_Fasciculus_L 18 59.6667 4.16519 813
Anterior_Commissure 14 56.7143 3.87255 668
Optic_Radiation_L 13 55.2308 3.62813 571
Corticostriatal_Tract_Posterior_L 12 56.1667 3.43994 522
Dentatorubrothalamic_Tract_R 12 59.8333 3.54331 590
Superior_Longitudinal_Fasciculus2_L 11 58.5454 3.41103 535
Corticospinal_Tract_L 11 53.8182 3.23737 443
Uncinate_Fasciculus_R 10 54.2 3.03845 393
Reticular_Tract_L 10 63.2 2.82808 397



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop position error average


Glass Brain displaying tracts that had MD positively and negatively correlated with loop position error average







post

Positive Correlations (FDR = 1.0000)

no significant tracts



Negative Correlations (FDR = 0.081145)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 133 61.7895 9.04126 3967
Corpus_Callosum_Forceps_Major 125 62.208 9.96534 4852
Cerebellum_R 90 54.6889 8.49819 3102
Corpus_Callosum_Body 87 63.8391 8.22628 3393
Fornix_L 78 61.641 6.27289 1905
Corticostriatal_Tract_Posterior_R 72 55.3611 7.3969 2379
Inferior_Longitudinal_Fasciculus_R 60 63.4 7.4867 2791
Cerebellum_L 48 53.5 6.33254 1685
Corpus_Callosum_Forceps_Minor 43 59.8605 6.54183 2012
Arcuate_Fasciculus_R 32 58.375 5.05598 1172
Inferior_Fronto_Occipital_Fasciculus_L 31 59.9355 5.19006 1268
Dentatorubrothalamic_Tract_L 24 55.0833 4.77885 988
Arcuate_Fasciculus_L 23 55.4783 4.47611 873
Inferior_Fronto_Occipital_Fasciculus_R 23 58.2609 4.94075 1117
Fornix_R 23 60.8696 3.68165 648
Thalamic_Radiation_Superior_L 19 57.5789 3.83761 666
Middle_Cerebellar_Peduncle 19 62.4211 3.91911 753
Inferior_Longitudinal_Fasciculus_L 18 59.6667 4.16519 813
Anterior_Commissure 14 56.7143 3.87255 668
Optic_Radiation_L 13 55.2308 3.62813 571
Corticostriatal_Tract_Posterior_L 12 56.1667 3.43994 522
Dentatorubrothalamic_Tract_R 12 59.8333 3.54331 590
Superior_Longitudinal_Fasciculus2_L 11 58.5454 3.41103 535
Corticospinal_Tract_L 11 53.8182 3.23737 443
Uncinate_Fasciculus_R 10 54.2 3.03845 393
Reticular_Tract_L 10 63.2 2.82808 397



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop position error average


Glass Brain displaying tracts that had MD positively and negatively correlated with loop position error average







PEri Post

Positive Correlations (FDR = 0.411765)

no significant tracts



Negative Correlations (FDR = 0.050080)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 385 55.7922 7.69402 2594
Corpus_Callosum_Tapetum 320 59.7375 8.99486 3796
Cerebellum_R 108 53.2963 6.43622 1734
Thalamic_Radiation_Superior_L 82 59.4878 5.01914 1177
Corpus_Callosum_Body 54 64.1111 5.0083 1263
Fornix_R 20 53.9 3.38828 486
Inferior_Fronto_Occipital_Fasciculus_L 19 55.7895 2.87034 361
Optic_Radiation_L 18 53.8889 3.07038 399
Cingulum_Frontal_Parietal_L 13 54.7692 2.28197 224



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop position error average


Glass Brain displaying tracts that had MD positively and negatively correlated with loop position error average







Summary




Scatter Plots

Men and women have the following tracts in common for MD - Fornix L - Fornix R - Thalamic Radiation Superior L

For men there is a positive association and for women there is a negative association

AD

All subjects

Positive Correlations (FDR = 0.122995)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 108 53.7963 4.93259 1028



Negative Correlations (FDR = 0.016199)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 694 56.0461 6.58545 1909
Fornix_L 469 54.8529 6.87117 2034
Cingulum_Frontal_Parietal_L 13 53.6923 2.52096 268



Figures

Slice overlay image displaying ROIs with tracts that had AD positively correlated with loop position error average


Slice overlay image displaying ROIs with tracts that had AD negatively correlated with loop position error average


Glass Brain displaying tracts that had AD positively and negatively correlated with loop position error average







Men

Positive Correlations (FDR = 0.022862)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 3174 57.748 11.6247 6129
Fornix_R 743 54.8102 9.06958 3541
Thalamic_Radiation_Superior_L 672 56.8839 9.38019 3931
Corpus_Callosum_Forceps_Major 251 56.7649 6.10563 1662
Cingulum_Frontal_Parietal_L 180 59.7889 5.4641 1402
Cerebellum_L 105 51.9429 5.63631 1296
Thalamic_Radiation_Posterior_L 96 54.5 5.36273 1231
Thalamic_Radiation_Anterior_L 61 52.6557 3.94616 644
Thalamic_Radiation_Superior_R 45 53.5556 4.38558 809
Cingulum_Frontal_Parahippocampal_L 22 60.7273 3.80354 690



Negative Correlations (FDR = 0.019520)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 205 52.4878 7.24192 2162
Fornix_R 54 55 3.99087 688
Cerebellum_L 32 52.125 4.02732 664



Figures

Slice overlay image displaying ROIs with tracts that had AD positively correlated with loop position error average


Slice overlay image displaying ROIs with tracts that had AD negatively correlated with loop position error average


Glass Brain displaying tracts that had AD positively and negatively correlated with loop position error average







Women

Positive Correlations (FDR = 0.037037)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 12 52.6667 2.86277 339



Negative Correlations (FDR = 0.000098)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1710 56.4877 10.3603 4762
Fornix_R 506 55.9842 8.30536 3033
Thalamic_Radiation_Superior_L 372 55.4355 8.72444 3314
Corpus_Callosum_Tapetum 223 57.3812 9.49264 4061
Cingulum_Frontal_Parietal_L 213 59.4836 5.00223 1169
Corpus_Callosum_Body 61 55.8033 5.32122 1241
Inferior_Fronto_Occipital_Fasciculus_L 41 56 3.92044 676
Optic_Radiation_L 39 55.2308 3.87991 653
Cerebellum_R 30 53.7333 3.34075 471
Thalamic_Radiation_Superior_R 26 54.9231 4.06843 714
Thalamic_Radiation_Anterior_L 22 55.1818 2.99978 390
Cingulum_Frontal_Parahippocampal_L 18 61.8889 3.34232 543
Thalamic_Radiation_Posterior_L 17 61.1765 3.6411 637



Figures

Slice overlay image displaying ROIs with tracts that had AD positively correlated with loop position error average


Slice overlay image displaying ROIs with tracts that had AD negatively correlated with loop position error average


Glass Brain displaying tracts that had AD positively and negatively correlated with loop position error average







pre

Positive Correlations (FDR = 1.000000)


Negative Correlations (FDR = 0.026400)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 776 58.3557 8.95452 3675
Cerebellum_R 291 56.7766 7.96361 2828
Fornix_R 284 56.0704 7.05679 2193
Thalamic_Radiation_Superior_L 36 54.1111 3.70696 584



Figures

Slice overlay image displaying ROIs with tracts that had AD negatively correlated with loop position error average


Glass Brain displaying tracts that had AD positively and negatively correlated with loop position error average







peri

Positive Correlations (FDR = 1.000000)



Negative Correlations (FDR = 0.006482)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 201 67.6418 10.4171 5765
Cerebellum_R 108 54.2407 8.96387 3423
Corpus_Callosum_Forceps_Major 83 62.8434 8.03808 3189
Fornix_L 63 60.1587 5.91125 1651
Cerebellum_L 58 53.7586 6.614 1847
Corpus_Callosum_Body 50 60.08 6.72019 2131
Inferior_Longitudinal_Fasciculus_L 39 56.7179 5.66978 1432
Arcuate_Fasciculus_R 36 62.2778 5.18109 1313
Corticostriatal_Tract_Posterior_R 35 57.8286 6.26731 1784
Middle_Cerebellar_Peduncle 35 54.6857 5.60018 1347
Inferior_Fronto_Occipital_Fasciculus_R 32 56.25 6.00296 1592
Fornix_R 29 66.2759 4.18347 911
Dentatorubrothalamic_Tract_R 27 60.5926 5.66269 1526
Inferior_Longitudinal_Fasciculus_R 26 59 5.94547 1638
Corticospinal_Tract_R 26 61.4615 4.39401 932
Optic_Radiation_L 25 59.2 4.56045 967
Corticospinal_Tract_L 22 58.6364 4.21967 820
Cingulum_Parolfactory_R 21 61.3333 3.6987 659
Inferior_Fronto_Occipital_Fasciculus_L 19 59.1579 4.56207 967
Dentatorubrothalamic_Tract_L 19 56.3158 4.44016 872
Corticopontine_Tract_Parietal_L 17 61.7647 3.43686 573
Corticostriatal_Tract_Posterior_L 17 55.7647 4.14366 752
Thalamic_Radiation_Posterior_R 17 57.1765 4.31469 836
Superior_Longitudinal_Fasciculus2_L 16 56.375 3.4171 517
Arcuate_Fasciculus_L 15 59.4667 4.35055 884
Thalamic_Radiation_Anterior_R 14 53.2857 3.64163 555
Thalamic_Radiation_Posterior_L 14 57.4286 4.22988 807
Medial_Lemniscus_R 13 62 3.62817 641
Corpus_Callosum_Forceps_Minor 12 58.5 3.48181 557
Cingulum_Frontal_Parietal_R 11 56.5455 3.37545 506
Middle_Longitudinal_Fasciculus_R 11 53.4546 3.74241 588
Corticopontine_Tract_Parietal_R 11 55.4545 3.33357 484
Anterior_Commissure 10 57.4 3.31026 494



Figures

Slice overlay image displaying ROIs with tracts that had AD negatively correlated with loop position error average


Glass Brain displaying tracts that had AD positively and negatively correlated with loop position error average







post

Positive Correlations (FDR = 1.000000)



Negative Correlations (FDR = 0.031666)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 95 55.3684 8.31001 3003
Cerebellum_L 38 53.3158 6.21608 1618
Fornix_L 37 57.2432 4.64971 972
Corpus_Callosum_Tapetum 28 55.3571 5.10034 1131
Corpus_Callosum_Forceps_Major 26 61.3077 4.90825 1160
Inferior_Longitudinal_Fasciculus_R 21 55.3333 4.24466 783
Fornix_R 21 57.1429 3.19453 458
Thalamic_Radiation_Superior_L 17 60.1176 3.0596 442
Corpus_Callosum_Body 17 58.3529 4.30152 848
Inferior_Fronto_Occipital_Fasciculus_R 12 53.6667 3.64499 560
Corticostriatal_Tract_Posterior_R 12 52.8333 3.50235 509
Arcuate_Fasciculus_L 11 52 3.1607 408
Middle_Cerebellar_Peduncle 11 53.6364 3.04269 390



Figures

Slice overlay image displaying ROIs with tracts that had AD negatively correlated with loop position error average


Glass Brain displaying tracts that had AD positively and negatively correlated with loop position error average







Peri and Post

Positive Correlations (FDR = 0.477235)



Negative Correlations (FDR = 0.075829)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 2529 59.6362 15.5084 11265
Fornix_L 970 55.5938 10.9507 5236
Corpus_Callosum_Forceps_Major 659 57.5144 10.448 4931
Corpus_Callosum_Body 438 55.3151 8.89324 3436
Thalamic_Radiation_Superior_L 391 56.9719 8.94846 3583
Cerebellum_R 389 53.3882 9.81939 4043
Cingulum_Frontal_Parietal_L 189 60.0106 5.10227 1227
Fornix_R 141 53.6738 6.17422 1607
Inferior_Fronto_Occipital_Fasciculus_L 132 54.9242 6.47041 1806
Cerebellum_L 103 53.2233 6.78433 1924
Optic_Radiation_L 92 53.8043 5.50151 1279
Thalamic_Radiation_Anterior_L 85 53.9059 4.09512 710
Inferior_Longitudinal_Fasciculus_L 62 54.2581 5.18353 1145
Anterior_Commissure 25 61.12 3.79404 691
Middle_Longitudinal_Fasciculus_R 20 51.8 4.06117 671
Thalamic_Radiation_Superior_R 19 57.0526 3.20403 460
Arcuate_Fasciculus_L 17 67.7647 2.60079 360
Cingulum_Frontal_Parahippocampal_L 13 62.6154 3.10459 474
Thalamic_Radiation_Posterior_L 12 60 3.22132 489



Figures

Slice overlay image displaying ROIs with tracts that had AD negatively correlated with loop position error average


Glass Brain displaying tracts that had AD positively and negatively correlated with loop position error average







Summary







RD

All subjects

Positive Correlations (FDR = 0.909414)
Not significant



Negative Correlations (FDR = 0.035990 )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 1041 56.2171 7.72962 2638
Fornix_L 801 56.5418 8.39274 3128
Corpus_Callosum_Body 79 51.8734 5.68775 1318
Cingulum_Frontal_Parietal_L 53 57.4717 3.70616 620
Corpus_Callosum_Tapetum 37 56.0541 4.14667 757
Thalamic_Radiation_Superior_L 25 54.64 3.89185 650



Figures

Slice overlay image displaying ROIs with tracts that had AD negatively correlated with loop position error average


Glass Brain displaying tracts that had AD positively and negatively correlated with loop position error average







Men

Positive Correlations (FDR = 0.012641 )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 2731 58.9403 11.0946 5698
Fornix_R 505 55.5762 8.63282 3253
Thalamic_Radiation_Superior_L 304 56.5724 7.89574 2770
Corpus_Callosum_Forceps_Major 197 59.5939 6.38976 1911
Thalamic_Radiation_Superior_R 27 57.2593 3.31433 494
Cerebellum_L 26 53.3846 3.33022 465
Corpus_Callosum_Tapetum 24 54.75 3.36533 487
Cingulum_Frontal_Parietal_L 14 64.5714 2.9788 450
Thalamic_Radiation_Posterior_L 10 58 3.00739 412



Negative Correlations (FDR = 0.062762 )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 94 52.4043 5.55705 1271
Fornix_R 23 54.5217 3.56426 544



Figures

Slice overlay image displaying ROIs with tracts that had AD positively correlated with loop position error average


Slice overlay image displaying ROIs with tracts that had AD negatively correlated with loop position error average


Glass Brain displaying tracts that had AD positively and negatively correlated with loop position error average







Women

Positive Correlations (FDR =0.125000 )

Not significant



Negative Correlations (FDR = 0.001068 )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1985 58.4594 11.1528 5711
Fornix_R 904 56.7965 8.33903 3102
Corpus_Callosum_Tapetum 259 58.9189 8.6869 3492
Corpus_Callosum_Body 250 57.392 8.53424 3283
Thalamic_Radiation_Superior_L 193 58.5285 6.69592 2061
Cingulum_Frontal_Parietal_L 63 60.8254 3.68867 650
Thalamic_Radiation_Anterior_L 18 55.2222 2.42951 256
Thalamic_Radiation_Posterior_L 17 59.7647 3.39493 541
Thalamic_Radiation_Superior_R 15 57.3333 2.9916 403



Figures

Slice overlay image displaying ROIs with tracts that had AD negatively correlated with loop position error average


Glass Brain displaying tracts that had AD positively and negatively correlated with loop position error average







pre

Positive Correlations (FDR = 1.000000 )

Not significant



Negative Correlations (FDR = 0.039982 )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 728 60.2692 8.68078 3567
Fornix_R 266 57.5414 5.78226 1511
Cerebellum_R 77 56.0519 4.98504 1094
Corpus_Callosum_Body 17 58.7059 3.03605 425
Corpus_Callosum_Tapetum 16 59.875 2.88719 392
Cingulum_Frontal_Parietal_L 15 51.7333 1.43784 84
Corpus_Callosum_Forceps_Major 14 60.4286 3.06206 445
Thalamic_Radiation_Superior_L 11 53.8182 2.38285 240
Optic_Radiation_L 10 52.8 2.91346 352



Figures

Slice overlay image displaying ROIs with tracts that had AD negatively correlated with loop position error average


Glass Brain displaying tracts that had AD positively and negatively correlated with loop position error average







peri

Positive Correlations (FDR =1.000000 )
Not significant



Negative Correlations (FDR =0.016583 )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 123 60.6179 9.4992 4296
Corpus_Callosum_Forceps_Major 108 59.9259 9.27631 4050
Corpus_Callosum_Tapetum 92 61.4565 8.23211 3271
Fornix_L 86 62.2093 6.20471 1881
Cerebellum_R 78 54.1026 8.08996 2781
Corpus_Callosum_Forceps_Minor 61 57.6393 7.30086 2413
Cerebellum_L 53 53.283 6.75581 1910
Fornix_R 26 58.2308 3.48671 556
Corticostriatal_Tract_Posterior_R 25 52.8 4.77369 945
Inferior_Longitudinal_Fasciculus_R 21 60.0952 4.79236 1084
Middle_Cerebellar_Peduncle 19 60.9474 3.71883 662
Thalamic_Radiation_Posterior_R 17 55.0588 4.43876 852
Arcuate_Fasciculus_R 16 55.5 4.18654 764
Dentatorubrothalamic_Tract_L 15 57.3333 3.90029 685
Thalamic_Radiation_Superior_L 14 61.8571 3.33702 541
Arcuate_Fasciculus_L 13 52.3077 3.40389 476
Reticular_Tract_R 12 56.1667 3.02626 404
Inferior_Fronto_Occipital_Fasciculus_R 10 53.8 2.93504 364



Figures

Slice overlay image displaying ROIs with tracts that had AD negatively correlated with loop position error average


Glass Brain displaying tracts that had AD positively and negatively correlated with loop position error average







post

Positive Correlations (FDR =1.000000 )

Not significant



Negative Correlations (FDR =0.048898 )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 115 55.8957 10.2763 4636
Fornix_L 94 57.7234 6.11093 1693
Middle_Cerebellar_Peduncle 66 58.8485 7.90608 2889
Corpus_Callosum_Body 50 57.68 7.56415 2592
Cerebellum_L 41 56.3902 5.98229 1585
Corpus_Callosum_Tapetum 37 60.2703 6.67485 2109
Corpus_Callosum_Forceps_Major 35 63.2571 6.45172 2068
Corpus_Callosum_Forceps_Minor 33 55.6364 5.93079 1537
Inferior_Longitudinal_Fasciculus_R 25 58.8 5.47635 1385
Dentatorubrothalamic_Tract_R 23 59.3043 5.27897 1298
Fornix_R 22 55.6364 3.50234 536
Arcuate_Fasciculus_L 20 53.7 4.97052 1042
Corticospinal_Tract_R 18 62.6667 4.11148 832
Arcuate_Fasciculus_R 15 59.2 4.28069 852
Superior_Longitudinal_Fasciculus2_R 15 62 4.178 850
Inferior_Fronto_Occipital_Fasciculus_R 13 56.7692 4.30156 825
Inferior_Longitudinal_Fasciculus_L 13 56.7692 3.723 618
Corticostriatal_Tract_Posterior_R 13 61.0769 4.2831 880
Thalamic_Radiation_Superior_L 13 60.6154 3.47836 576
Dentatorubrothalamic_Tract_L 12 54.8333 3.80954 625
Corticospinal_Tract_L 11 55.6364 3.21621 452
Corticostriatal_Tract_Anterior_R 11 53.6364 3.63624 557
Cingulum_Frontal_Parietal_R 10 61.8 3.6679 653
Frontal_Aslant_Tract_R 10 55.6 3.18148 442
Medial_Lemniscus_R 10 65.2 3.35675 577



Figures

Slice overlay image displaying ROIs with tracts that had AD negatively correlated with loop position error average


Glass Brain displaying tracts that had AD positively and negatively correlated with loop position error average







PEri Post

Positive Correlations (FDR =0.312843 )

Not significant



Negative Correlations (FDR =0.089524 )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 766 56.1253 9.12449 3670
Corpus_Callosum_Tapetum 416 58.2067 8.47817 3286
Cerebellum_R 162 53.5679 7.02113 2074
Thalamic_Radiation_Superior_L 113 58.0177 5.86421 1567
Corpus_Callosum_Body 67 56.7463 6.01221 1611
Fornix_R 56 54.6071 4.84557 1007
Corpus_Callosum_Forceps_Minor 41 55.7073 4.36598 834
Cingulum_Frontal_Parietal_L 38 56.5263 4.26086 806
Corpus_Callosum_Forceps_Major 14 52.7143 3.09661 397
Optic_Radiation_L 12 53.6666 2.55892 276



Figures

Slice overlay image displaying ROIs with tracts that had AD negatively correlated with loop position error average


Glass Brain displaying tracts that had AD positively and negatively correlated with loop position error average







Summary